While at least 70% of prostate cancer, colon cancer, and breast cancer samples presented a cytoplasmic distribution of E2F7, fewer than 30% of corresponding paracancerous tissues presented a cytoplasmic distribution (59), suggesting that the cytoplasmic distribution of E2F7 may be an important mediator of cancer development. The gene discussed is E2F7; the disease is malignant colon neoplasm.