Both genetic (Grin1-KD) and pharmacological (MK-801) mouse models show robust schizophrenia-like behaviors (Mohn et al., 1999; Abdallah et al., 2011; Milenkovic et al., 2014; Islam et al., 2017; Mielnik et al., 2021; Lipina et al., 2022), offering valuable tools for testing our hypothesized novel pharmacological strategy. This evidence concerns the gene GRIN1 and schizophrenia.