CD274 and colorectal cancer: Some tumor cells can secrete inhibitory mediators of T cells and natural killer cells, including interleukin 10, reactive oxygen species, transforming growth factor beta, and express immune checkpoint molecules such as PD-L1.[25,26] And produce inflammatory mediators interleukin 1beta, interleukin 6 and other inflammatory factors to enhance inflammation.[27] Employing SNPs, our findings divulged a potent association between 7 phenotypes of T cells and colorectal cancer, with each of them serving as protective factor, corroborated by an integration of multiple 2-sample MR.