Intriguingly, these signatures function as protective factors in the context of colorectal cancer, including CD28 on CD39+ CD4+ T cell (ebi-a-GCST90001892; IVW: OR [95%CI] = 0.933 [0.901–0.966], P < .001), CD39+ activated CD4 regulatory T cell %CD4 regulatory T cell (ebi-a-GCST90001491; IVW: OR [95%CI] = 0.973 [0.957–0.989], P = .001), IgD on unswitched memory B cell (ebi-a-GCST90001826; IVW: OR [95%CI] = 0.900 [0.844–0.960], P = .001), et al. The robustness of the above exposure factors is second. This evidence concerns the gene ENTPD1 and colorectal cancer.