We employing IVW as the primary algorithm and also performed a comprehensive evaluation of the heterogeneity and multifarious impact effect, which conclude that 4 inflammatory protein factors (i.e., fibroblast growth factor 19 levels, beta-nerve growth factor levels, programmed cell death 1 ligand 1 levels, Leukemia inhibitory factor receptor levels) are risk factors for colorectal cancer and 3 inflammatory protein factors (i.e., Fmsrelated tyrosine kinase 3 ligand levels, interleukin-2 receptor subunit beta levels, interferon gamma levels) are protective factors for colorectal cancer. The gene discussed is LIFR; the disease is colorectal cancer.