CXCL8 and Sepsis: Corticosteroids are administered to treat septic shock by suppressing nuclear factor KB, which leads to a decrease in interleukin (I) -1, IL-6, tumor necrosis factor (TNF)-α, IL-8, TNF receptor 1 and 2.[42] Furthermore, HC suppresses the activity of nitric oxide (NO) synthase and hinders the vasodilation caused by sepsis that is mediated by NO.[43] Exogenous corticosteroids decrease the levels of endogenous cortisol, which helps to relieve the adrenal instability that contributes to hemodynamic instability in septic shock.[44]