PTCH1 and cleft lip: Nearly 100 loci of PTCH1 gene mutations were listed on the website of the Department of Molecular Genetics, Kitasato University, Japan, which were widely distributed on most exons, especially exon 2, 3, 9, and 19.[6,7] Different mutations of PTCH1 may lead to different clinical manifestations in patients, and the more common manifestations are falx calcification, bone malformations, ocular abnormalities, cleft lip and palate and other diseases, with the vast majority of patients showing the manifestations before the age of 20 years.