PTCH1 and basal cell carcinoma: According to the latest diagnostic criteria of NBCCS,[3] the mother and daughter could have NBCCS: dozens of basal cell carcinoma lesions, out of proportion to sun exposure and skin type; first-degree relatives with NBCCS, and they had PTCH1 gene mutation; the proband’s second daughter had punctate depressions on the palms and soles.