PTCH1 is the key component of Hedgehog (Hh) signaling pathway, which is involved in many physiological processes in the body.[8] Recently, Hh pathway inhibitors vismodegib and sonidegib have been used in patients with basal cell carcinoma following surgery or radiation therapy.[9,10] Another limitation of this study is that we did not evaluate the application of Hh pathway inhibitors in our patients. The gene discussed is PTCH1; the disease is basal cell carcinoma.