Firstly, severe inflammatory response in COVID-19 may lead to increased capillary permeability and leakage of albumin into interstitial space.[19,20] Secondly, the systemic inflammatory response can also accelerate albumin catabolism, decrease the synthesis of albumin, and downregulate hepatic secretion of albumin.[21,22] Thirdly, serum albumin concentrations in the general population peak at about 20 years of age, and then declines with age.[4]. This evidence concerns the gene ALB and COVID-19.