SIRT1 and type 2 diabetes mellitus: The ROC analysis of using SIRT1 gene to identify experimental subject cases is shown in Figure 2B. The AUC value of T2DD was 0.914, the AUC value of HP was 0.721, and the AUC value of T2DM was 0.701, indicating that the extraction of SIRT1 gene could be used to identify healthy people and type 2 diabetes.