A cross-sectional study involving 120 diabetic patients showed significant changes in the expression of the SIRT1 gene in peripheral blood and was correlated with the degree of depression (Rs = 0.452; P = .003), which indicated that the SIRT1 gene became a potential biomarker for assessing the onset of depression in patients with diabetes.[11,12] The experimental results of the research showed that using the SIRT1 gene had higher accuracy in identifying patients with type 2 diabetes comorbid depression, and the AUC value of the ROC analysis chart was 0.914. The gene discussed is SIRT1; the disease is major depressive disorder.