TNF and rheumatoid arthritis: These include polymorphisms in genes like IL-2, IL-6, and TNF-α, which are critical in immune responses.[28] The shared genetic predisposition suggests a common autoimmune mechanism, where susceptibility in immune regulation may lead to inflammation in both joints and ocular tissues.[29] At the molecular level, chronic inflammation mediated by pro-inflammatory cytokines characterizes both iridocyclitis and RA.