NOD2 and uveitis: In CD, the NOD2/CARD15 gene is a well-established risk factor, playing a crucial role in innate immune responses to bacterial antigens.[31] Similarly, polymorphisms in genes like IL-23R and TNFSF15 have been associated with both CD and uveitis, suggesting a common genetic framework that predisposes individuals to inflammatory responses.[32] These shared genetic factors highlight a potential link between gastrointestinal and ocular inflammation, driven by immune system dysregulation.