BDNF and Parkinson disease: By applying the cortical basal nucleus thalamic cortical circuit to regulate function, cortical excitability can approach a normal state and improve clinical symptoms in patients with PD.[21] (2) Regulating the plasticity response of neural networks: rTMS can enhance interactions between cortical regions.[22,23] (3) Activating the dopamine pathway in the midbrain striatum promotes dopamine release.[24,25] (4) Promotion of brain-derived neurotrophic factor synthesis.[26]