The meta-analysis results showed that high-frequency stimulation of the M1 region can reduce the UPDRS-III score in patients and regulate the expression of dopamine, interferon, brain-derived neurotrophic factors, etc. High frequency 10 Hz stimulation of the M1 region has a more effective effect on Parkinson’s movement.[43–45] Consistent with the findings of this study, high-frequency rTMS stimulation of the M1 region significantly improved overall motor function (UPDRS III), balance function (TUG), movement speed (10MW), and quality of life (PDQ-39) in Parkinson’s. Here, BDNF is linked to Parkinson disease.