Patients with low serum ferritin levels are more prone to developing CRC, suggesting a link between iron deficiency and CRC onset.[24,25] Hepcidin, often abnormally expressed in CRC tumor epithelium, may exacerbate tumor parameters by enhancing intracellular iron accumulation through the suppression of the iron export protein ferroportin. This evidence concerns the gene PROS1 and Iron deficiency anemia.