Patients with low serum ferritin levels are more prone to developing CRC, suggesting a link between iron deficiency and CRC onset.[24,25] Hepcidin, often abnormally expressed in CRC tumor epithelium, may exacerbate tumor parameters by enhancing intracellular iron accumulation through the suppression of the iron export protein ferroportin. The gene discussed is SLC40A1; the disease is Iron deficiency anemia.