Patients with low serum ferritin levels are more prone to developing CRC, suggesting a link between iron deficiency and CRC onset.[24,25] Hepcidin, often abnormally expressed in CRC tumor epithelium, may exacerbate tumor parameters by enhancing intracellular iron accumulation through the suppression of the iron export protein ferroportin. Here, PROS1 is linked to colorectal carcinoma.