Research has demonstrated that total hemoglobin concentration (THC) increases, while oxygen saturation (StO2) decreases in CRC tissues as tumors evolve from benign to malignant states, signifying a shift toward hypoxia within the tumor microenvironment.[9] Key regulatory mechanisms involving the mTOR pathway and PP2A phosphatase affect PHD2 phosphorylation, thereby controlling HIF1α levels essential for cellular survival in hypoxic conditions. This evidence concerns the gene HIF1A and neoplasm.