Therefore, saponins have a notable impact on sphingolipid pathogenesis, with this group of lysosomal storage diseases identified by sphingolipid buildup.23,24 According to current data from the Human Gene Mutation Database, fewer than 15 mutations in the PSAP gene have been identified in MLD.22,25. The gene discussed is PSAP; the disease is metachromatic leukodystrophy.