Despite these limitations, here we showed that the implementation of NDM to cross-sectional structural connectome data is a valuable tool to predict future patterns of atrophy and spreading of pathology in the main variants of the FTD spectrum, particularly for those variants with a more definite neuropathological underpinning (i.e. TDP-43 for svPPA/sbvFTD and tau for nfvPPA). This evidence concerns the gene TARDBP and frontotemporal dementia.