CYP2C9 and Hepatic steatosis: BBR is metabolized in the liver by CYP2C9 (analogous to Cyp2c29 in mice) to produce 6‐hydroxy‐BBR and other hydroxylated metabolites.[20] Our study highlighted profound perturbations in the expression and activity of CYP450 enzymes associated with hepatic steatosis, as supported by comprehensive in vivo and in vitro experimental evidence and clinical transcriptomic data.