Vimentin, a type III cytoskeletal intermediate filament protein, mainly serves in cell morphology maintenance, organelle organization, cell migration, and signal transduction.[7] In addition to its well‐established intracellular cytoskeletal network, vimentin has also been found to associate with the plasma membrane, termed cell‐surface vimentin (CSV).[8] In recent years, there has been a burgeoning focus on elucidating the role of intracellular vimentin in bacterial and viral infections.[9] However, the function of CSV in infections remains largely unexplored. This evidence concerns the gene VIM and viral infectious disease.