A previous study indicated that human hepatoma‐derived Huh7 cells cultured in the presence of 1% dimethyl sulfoxide (DMSO) turn cytologically differentiated and transition into a nondividing in vivo‐like state, characterized by the induction of hepatocyte‐specific genes.[13] We then set up the DMSO‐culture system to investigate the potential function of vimentin under more physiologically relevant conditions (Figure 1F). This evidence concerns the gene VIM and hepatocellular carcinoma.