Of relevance to the process of Mtr infection studied here, activated calpain can also bring about: (3) an increase in cellular infection with Mtr (due to calpain‐mediated increase in actin depolymerization) especially in chronic Chagas cardiomyopathy where MMP‐2 and MMP‐9 (which are activated by calpains) play a role in cardiac remodelling (Baron et al., 2022) and (4) an increase in lEV release (due to the action of calpain on cortactin and other cytoskeletal proteins) (Taylor et al., 2020). Here, DNM2 is linked to infection.