PTK2 and cancer: These include: (1) modulation of inflammation (through calpain‐mediated activation and release of matrix metalloproteinase proteinases (MMPs) in turn regulating chemokine activity) (Ji et al., 2016) or increasing cancer cell invasion (also due to calpain's activation and release of MMPs) (Chen et al., 2019) and (2) increase in cell migration (due to calpain‐mediated proteolysis of talin and FAK) (Kerstein et al., 2017).