The increase of the proliferation marker Ki-67 with growth rate noted here was in support of previous clinical findings, as Ki-67 has often correlated with preoperative growth rate.33 Additionally, single-cell expression of Ki-67 (Fig. 1D) and the additional markers that correlated with growth rate (Supplementary Fig. S1) were visualized spatially matched to the ROI in Fig. 1B to display the heterogeneous nature of marker expression across the tumour micro-environment. Here, MKI67 is linked to neoplasm.