Mice with ovalbumin (OVA)-induced asthma presented with increased pulmonary NLRP3, caspase-1 and IL-1β expression, while the blockage of the NLRP3/caspase-1/IL-1β pathway attenuated bronchial inflammation in asthmatic mice (Chen et al., 2022). The gene discussed is CASP1; the disease is asthma.