Nootkatone, which is an antioxidant sesquiterpenoid identified in a number of Citrus species, alleviated bronchial inflammation and mucus hypersecretion in mice with OVA-induced asthma (Gai et al., 2023) Mechanistically, Nootkatone mitigated the ROS-mediated NLRP3 activation and pyroptosis in asthmatic mice, and in IL-13-stimulated human AECs (Gai et al., 2023). This evidence concerns the gene NLRP3 and asthma.