During the development of asthma, both non-immune cells, such as AECs, and immune cells, such as macrophages, neutrophils, eosinophils and T cells, may undergo pyroptosis through the inflammasome-mediated, caspase-1-dependent canonical pathway or caspase-4/5/11-dependent noncanonical pathway, resulting in the secretion of proinflammatory cytokines and DAMP molecules. This evidence concerns the gene CASP4 and asthma.