However, the blockade of the NLRP3/caspase-1 axis attenuated the bronchial neutrophilic inflammation in mice exposed to toluene diisocyanate (TDI) (Chen et al., 2019), implying that the NLPR3/caspase-1 signaling promotes neutrophilic inflammation in asthma. The gene discussed is NLRP3; the disease is asthma.