Conversely, proatherogenic roles of CD163+ macrophages are also reported (155, 192, 193); indeed, in human and mouse atherosclerotic lesions M(Hb) CD163+ macrophages are also associated with promotion of angiogenesis, vessel permeability, and leucocyte infiltration through a mechanism involving Hb/Hp/CD163/HIF1α-mediated VEGF induction (194). This evidence concerns the gene GSTM1 and Atherosclerotic lesion.