reported in the 4T1 breast cancer and B16 melanoma models that fasting mimicking-diet (FMD) caused reduction in HO-1 expression in cancer cells, sensitizing them to doxorubicin and cyclophosphamide, promoting intratumoral accumulation of cytotoxic CD8+ T cells and reducing tumor-associated Tregs activation (37). Here, HMOX1 is linked to cancer.