Moreover, alteration of the Kelch-like ECH-associated protein 1/nuclear factor erythroid 2–related factor 2 (Keap1/Nrf2) pathway, a major regulator of cytoprotective responses to oxidative that continuously targets Nrf2 for proteasome degradation (32), is also associated with tumor progression (33). Here, NFE2L2 is linked to neoplasm.