HMOX1 and myocardial ischemia: The idea of targeting HO-1 in the myeloid cell compartment appears advantageous because the main functions of the heme-HO-1 system have been highlighted in the myeloid-mononuclear system (7, 144, 145) and because cardiac healing after myocardial ischemia depends on the recruitment and local expansion of myeloid cells, particularly macrophages (146).