HMOX1 and ischemia: Of relevance, the post-ischemic influx of Ly6G+ neutrophils and Ly6Chigh monocytes is further exacerbated in Hmox1-deficient hearts, while treatment with recombinant adeno-associated virus (rAAV)-encoding human Hmox-1 reverses such phenotype and attenuates post-ischemic inflammation, in a murine ischemia/reperfusion model (174).