NFE2L2 and colitis: Indeed, hemin-like compounds or adoptive transfer of hemin-activated macrophages reduced caerulein-induced pancreatitis, serum amylase and lipase, decreased pancreatic trypsin generation, and protected from lung injury (254), while activation of the NRF2/HO-1 pathway, through administration of Cobalt protoporphyrin IX (CoPP), induced macrophage differentiation toward a MarcohiHmox1hi anti-inflammatory erythrophagocytic phenotype, contributing to an overall decreased inflammatory profile in a murine model of colitis (255).