We have delineated the proteomic landscape of gout and identified 20 highly differentially expressed proteins (DEPs) in the serum of gout patients in comparison to that of healthy controls, which included VEGF-A, MMP-1, TGF-α, and OSM with corresponding area under the curve (AUC) values of 0.95, 0.95, 0.92, and 0.91 respectively. Here, TGFA is linked to gout.