ADCY4 and acute myeloid leukemia: Of these, ten genes (EVL, FHL2, HMGA1, HMGA2, MFHAS1, MINK1, PXN, SEMA3C, SRC, and ST6GALN AC4) showed lower expression in AML cells, and the remaining three genes (EXT2, PLD1, and PYCARD) showed elevated expression in AML cells compared with that in normal cells (Figure 1C; Supplementary Figures S2D, E).