The results were in line with our expectations, that low levels of ANXA1 (< 8.09 ng/mL) was able to predict the 30-day mortality, and the binary logistic regression analysis verified that ANXA1 was an independent protective factor in sepsis (B = -0.098, OR = 0.835, P = 0.020) (Supplementary Table S3). Here, ANXA1 is linked to Sepsis.