In addition, a significant increase in IgM+IgD+ PBs was detected in both MASLD (Fig. S5E) and HCC/NRASG12V/p19Arf-/- mice (Fig. S5L), which strongly correlated with the findings in the HCC/CaMIN model (Fig. 5F). The gene discussed is CD40LG; the disease is hepatocellular carcinoma.