Although not as strongly as in the aggressive HCC/CaMIN model, an increase in CD5+CD1d+ and CD5+CD1d- Bregs in CD19+B220+ B cells was detected in mice with MASLD (Fig. S2A, B) and HCC/NRASG12V/p19Arf-/- (Fig. S2M, N). The gene discussed is CD19; the disease is hepatocellular carcinoma.