A significant increase in IgM+IgD--, IgM+IgD+-, and IgA-IgD+- (Fig. 5E–H), but not IgA+IgD--expressing (Fig. 5H) CD19+B220+CD138+ B cells, was detected in the livers of HCC/CaMIN mice. The gene discussed is CD40LG; the disease is hepatocellular carcinoma.