Moreover, increases (not significant) in the frequencies of IgD-, IgM-, and IgA-expressing CD19+B220+CD5+CD1d+ and CD19-B220+CD5+CD1d- Bregs were detected in mice with MASLD (Fig. S3A–H) and HCC/NRASG12V/p19Arf-/- (Fig. S3I–P). The gene discussed is CD5; the disease is hepatocellular carcinoma.