Additionally, we detected significant overexpression of IL-10 and IgM+IgD+ on total CD19+CD20+ B cells, on CD19+CD20+CD5+CD1d+ Bregs and on CD19+CD20+CD27+ NSw MBCs in the blood of MASLD patients, which aligns with the findings obtained from MASLD mice. This evidence concerns the gene IL10 and metabolic dysfunction-associated steatotic liver disease.