VE6-T2 cells were pre-transfected with control, chimeric, 3′UTR-, NSP1-, and NSP2-specific SARS-CoV-2 DsiRNA swarms, followed by infection with BQ.1.1 or XBB.1.5 variants of SARS-CoV-2 at 21 h p.t. at MOI 0.01. Here, SH2D3A is linked to infection.