Besides the above membrane transport and fusion‐related proteins, the surfaces of EVs also contain various other transmembrane proteins with scaffolding functions, for instance, IL‐6,50 PD‐L1,51 EGFR, T‐cell receptor (TCR),52 flotillin 1 and 2,53 which are closely related to poor tumor immunity and prognosis. The gene discussed is CD274; the disease is neoplasm.