GCLC and endothelial dysfunction: Some mechanisms that explain the antioxidant effect of the LCHF include that βHB acts as a scavenger for hydroxyl radicals (•OH) (69) and upregulation of NRF-2 that modulates the expression of various genes involved in the antioxidant response such as glutamate-cysteine ligase catalytic subunit (GCLC), glutathione peroxidase, superoxide dismutase, catalase, and heme oxygenase (70) Our findings on NRF-2α and eNOS gene expressions further support its role in protecting against insulin resistance-related endothelial dysfunction induced by oxidative stress (71–73).