ASXL2 and Buschke-Ollendorff syndrome: Germline mutations in ASXL1 and ASXL2 are associated with specific genetic syndromes, such as Bohring–Opitz syndrome (BOS, OMIM #612990) (Fisher et al., 2003) and ASXL2-associated disorders (OMIM #612991) (Shashi et al., 2016).