The dysregulation of steroidogenesis is also apparent in the glucocorticoid and mineralocorticoid pathways in congenital adrenal hyperplasia (CAH) subtypes indicated by plasma steroids: in 11β-hydroxylase deficiency (11βOHD), DOC and deoxycortisol are elevated and cortisol and cortisone decreased; in 17α-hydroxylase deficiency (17αOHD) and cytochrome P450 oxidoreductase (PORD), CORT and 18OHCORT are increased and cortisol and cortisone decreased; and in 21-hydroxylase deficiency (21OHD), cortisol and cortisone are decreased (29). Here, POR is linked to classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency.