HMGA1 and non-small cell lung carcinoma: To construct a prognostic model for patients with NSCLC based on LRGs, univariate Cox regression analysis and subsequent LASSO regression were used to select the optimal combination of genes, yielding a set of six genes, namely, VIPR1, NEK2, HMGA1, FERMT1, SLC7A5, and TNS4 (Figures 4A, B).