Among these modules, yellow (M3) and green (M5) modules showed significant positive correlations with CD8+ T cells and significant negative correlations with gamma-delta T cells in AD, while turquoise module (M1) showed significant positive correlations with monocytes and MAIT cells and significant negative correlations with CD8+ T cells, gamma-delta T cells, and B cells in AD (Figure 3E). The gene discussed is CD8A; the disease is Alzheimer disease.