These results are consistent with the activation of cofilin by iso-Aβ42 established in our work: isomerized Asp7 is contained in more than 50% of Aβ molecules of amyloid plaques and is also enriched in the soluble fraction (Bugrova et al., 2021; Mukherjee et al., 2021), which explains the activation of cofilin in the brain of patients with AD and in vivo models of AD. The gene discussed is CFL1; the disease is Alzheimer disease.