Nevertheless, Kif18A does appear to be essential for survival of aneuploid cancer cells, perhaps by preventing unbearable chromosome mis-segregation in cells with more complicated spindle architecture, and is a vulnerability target for certain aneuploid cancers (Quinton et al., 2021; Cohen-Sharir et al., 2021; Marquis et al., 2021; Payton et al., 2024; Gliech et al., 2024). This evidence concerns the gene KIF18A and cancer.