LEP and Anorexia: Inflammation-associated anorexia, prevalent gastrointestinal symptoms due to slow intestinal transit, disrupted appetite regulation, and energy expenditure—linked to overexpression of leptin, increased bound leptin, irregular ghrelin secretion, and blunted ghrelin responses—correlate with liver disease severity and systemic inflammation, further reducing food intake quantity and frequency of spontaneous food consumption (12, 16).