CNNM2 and obesity due to melanocortin 4 receptor deficiency: Individuals with low levels of magnesium are at risk of developing conditions such as diabetes and obesity because the heart contains transporters and regulator channels that control magnesium movement, including TRPM7, TRPM7, MagT1, and CNNM2 for magnesium influx and SLC41A1 and SLC41A3 for magnesium efflux.