Linagliptin: ✔️Restored spatial reference memory as assessed by MWM. ✔️No effect on Tau phosphorylation in the hippocampus. ✔️Increased GLP-1 levels. ✔️Ameliorated high-fat diet-induced hyperglycemia. ✔️Decreased fasting blood glucose. ✔️Increased cerebral blood flow. ✔️No Effect on eNOS. This evidence concerns the gene NOS3 and Hyperglycemia.