In addition to these direct mechanisms of GLP-1 analogs on hepatocytes, GLP-1 analogs have been shown to significantly reduce serum C-reactive protein, interleukin-6, and tumor necrosis factor-α [42–44], which is involved in liver inflammation, development of hepatocellular carcinoma, and the progression of NASH. This evidence concerns the gene GCG and hepatocellular carcinoma.