Centrally, asprosin was able to cross the blood-brain barrier and directly acted on hunger-stimulating neurons known as agouti-related peptide neurons (AgRP) by a cAMP-dependent pathway in the hypothalamic arcuate nucleus (ARH), activating the feeding neural circuit to stimulate appetite which might lead to excessive energy absorption and obesity [40]. This evidence concerns the gene AGRP and obesity due to melanocortin 4 receptor deficiency.