PCLO and intervertebral disk degenerative disorder: Among the 19 potentially pathogenic SNVs/INDELs, 12 were de novo SNVs/INDELs in ASD/IDD genes (Table 3A): PTEN, CHD7, HNRNPH2, BSN, HNRNPR, MKX, SMARCA4, RPS6KA3, GLUL, TRIP12, TEK, and PCLO.