The most‐enriched term, regulation of growth, is associated with the mTOR signaling pathway, which plays an important role in syndromic ASD/IDD, such as FMR1 in fragile X syndrome, TSC in tuberous sclerosis, MECP2 in Rett syndrome, and PTEN.89, 90, 91, 92. Here, PTEN is linked to atypical Rett syndrome.