We found that misfolded tau from AD and other tauopathies like PSP and CBD, but not from NC and PiD, selectively seeded the 4RCF substrate (equivalent to the human 4R tau fragment, K18CFh) [16, 20] with a sensitivity of 80.5% and a specificity of 95.4%. The gene discussed is MAPT; the disease is tauopathy.