APOE and atrial fibrillation: Our sensitivity analyses to identify genetic variant association with age were reasonably powered (> 95% to identify APOE effect on age of 0.12 years/allele; minimal detectable effect size at 80% power = 0.09 years per allele, explains ~ 0.005% of the age variance; N = 350,000, alpha = 0.05/44, AF = 30%).