This study identified 25 immune-related DEGs, some of which were known to be associated with obesity, such as ELANE, SAA1, LCN2, OLFM4, CCL2, OAS3, BPI, AGR2, IL-17 A, DEFA1, DEFA3, MMP8, CTSG, DUOX1, and CXCL10, while BPIFA1, CRISP3, CEACAM8, IFIT1, RASD2, PRTN3, F2RL2, PDE1C, DEFA4, and FCN2 have not been reported to be related to obesity. Here, DEFA1 is linked to obesity due to melanocortin 4 receptor deficiency.