LRRK2 and Parkinson disease: Given that 32G13S mice showed elevated LRRK2, impaired mitochondrial activity, and reduced TH level, consistent with typical parkinsonism phenotypes, we next ought to examine the midbrain region of the mice, where the formation of α-synuclein deposition and the loss of dopaminergic (DA) neurons occur in PD [32, 37].