TGFB1 and neoplasm: These cells can stimulate and initiate the development of T-reg cells which together will collaborate to produce various immunosuppressive mediators including CXCL-5, CXCL-6, IL-10, PGE2, TGF-β, TSG6, and other supporting growth factors like VEGF, IGF1, basic fibroblast growth factor (bFGF), and HGF, all of which effectively inhibit the anti-tumor immune response [251–253].