TNFR2 expression on T-regs also promotes the production of various anti-apoptotic proteins (Bcl-2, Bcl-XL, Bcl-W, c-IAP1/2, A1/BFL-1, Cyclin D1, and MCL-1), leading to Tregs-mediated apoptosis resistance, extending their survival in BC TME. The gene discussed is TNFRSF1B; the disease is breast cancer.