TNFRSF1B and neoplasm: For instance, TNFR2-mediated activation of NF-κB or HER2 can trigger signals via STAT3 and Akt, which in turn activate the signaling cascades RAS/RAF/MEK/ERK, PI3K/Akt, and STATs, resulting in BCSC formation and survival as well as EMT initiation [107].STAT3 has a consensus response element in the promoter region of certain tumor genes.