When Liu et al. showed that beta-blockers improve CM proliferation via increasing the expression of ECT2 in children with tetralogy of Fallot (TOF), the most common cyanotic CHD and one that is characterized by RVPO, in the journal Science Translational Medicine [27] in late 2019, their results greatly interested cardiac surgeons [28–30] and quickly resulted in comments in The New England Journal of Medicine in early 2020 [31]. This evidence concerns the gene ECT2 and Tetralogy of Fallot.