Hence, the alcoholic extract of F. cretica plant was evaluated for its inhibitory effect on topo I enzyme using breast carcinoma (MCF-7) cell line and for the stimulation of apoptosis through caspase-9 assay in MCF-7 cell line, compared to doxorubicin as standard, and results showed inhibition of topo I and induction of caspase-9 levels as well. Here, CASP9 is linked to breast carcinoma.