Yet, a fraction (nearly 6%) of mice expressing 30% of Wdr47 (Wdr47tm1a/tm1a) survive and display severe neuroanatomical abnormalities including primary microcephaly and severe loss of commissural fibers, including CC, that manifest as hyperactivity and sensory motor gating abnormalities (Kannan et al, 2017). This evidence concerns the gene WDR47 and microcephaly.