WDR47 and microcephaly: Interestingly, the clinical manifestations of the patients are recapitulated in previously studied constitutive Wdr47 KO mouse models (Chen et al, 2020; Kannan et al, 2017; Liu et al, 2021) that display severe neuroanatomical phenotypes including CCD and microcephaly among other NAPs (Dataset EV1, Table 1 and Appendix fig. S2A).