WDR47 and neurodegenerative disease: The molecular alterations we observed in Wdr47-deficient developing neurons resemble pathological mechanisms that underlie neuronal loss in neurodegenerative diseases (Brady and Morfini, 2017; Dubey et al, 2015; Flippo and Strack, 2017; Mattson et al, 2008; Sferra et al, 2020).