While the p.(Pro650Leu) and the p.(His659Pro) variants partially restored the distribution of electroporated neurons at E18.5 (52%, 71%, 61%, 61% GFP+ cells in the uCP for NeuroD-Cre, WT, p.(Pro650Leu) and p.(His659Pro), respectively), expression the p.(Lys592Arg) and the p.(Asp466His) the two variants found in Patient M03, who presents with periventricular nodular heterotopia (Dataset EV1), totally failed to rescue the impaired migration of Wdr47-KO neurons (Fig. 8A,B). The gene discussed is WDR47; the disease is periventricular nodular heterotopia.