The tumour microtube marker nestin showed a significantly higher expression in the medulloblastoma subgroup enriched for LFS (SHH alpha, n = 51) as compared to sporadic medulloblastoma, as well as a significant association with overall survival (Supplementary Fig. 30A-B, bulk RNA sequencing; this was also true for other tumour microtube network relevant markers such as TTYH1 and GJA1, see Supplementary Fig. 30C) and also a widespread expression throughout tumours (Supplementary Fig. 31–32, n = 8 Visium LFS samples, difference to the 5 sporadic samples non-significant). This evidence concerns the gene TTYH1 and neoplasm.