TP53 and brain neoplasm: To test whether tumour microtubes in medulloblastoma build functional networks that have been related to vivid and rhythmic intracellular Ca transients in other brain tumour entities32,33, we performed live-cell imaging of calcium signalling activity in p53-deficient medulloblastoma cells with chromothripsis (Fig. 7F–H, Supplementary Movies 1–3).