The most common AEs leading to discontinuation were neutropenia (n = 3), thrombocytopenia (n = 3), and anemia (n = 3), while the most common AE leading to treatment interruption, or a drug holiday was liver dysfunction as evidenced by aspartate aminotransferase (AST) and alanine transaminase (ALT) levels above the institutional upper limit of normal (n = 6). The gene discussed is GPT; the disease is neutropenia.