In contrast, the top 25 DEGs that were downregulated are known to result in suppression of inflammatory and immune responses (U2af1l4, Psenen, Tbcb, Tmem147, Yif1b, S100b)75–80, prevent NSC differentiation (Clip3)81, or promote cancer metastases (Tbcb, Usf2, Tpm1)82–84 and resistance to drug or stress induced apoptosis (Aplp1, Rbm42, Capns1, Eif3k, Tpm1)85–89 (Fig. 9g). This evidence concerns the gene PSENEN and cancer.