Due to the ability of ASCL1 and OLIG2 to directly bind to the other’s loci and loci of cell cycle genes (Fig. 1e, g), we next investigated how alteration of the levels of ASCL1 and/or OLIG2 affect each other’s expression and tumor cell proliferation at both early and terminal stages of the various tumor types. Here, OLIG2 is linked to neoplasm.