All three subtypes were represented within both tumor models, with the proneural subtype expanded almost 2-fold (44%) in Ascl1-OE tumors at the expense of the classical subtype (31%) compared to control tumors (25% proneural, 45% classical), while the mesenchymal subtype was mostly unaffected (Fig. 6m). This evidence concerns the gene ASCL1 and neoplasm.