Not surprisingly, an overwhelming number of the top 25 upregulated DEGs are known to promote cancer metastasis and invasion (Crip1, Gfap, Sparcl1, Tmsb4x, Apoe, Ier2, Sparc, Cpe, Fabp5, Cdk2ap1, Jpt1, Vim, Ckb)52–64, NSC/GSC maintenance (Id1, Id3, Hes5, Gfap, Lgals1, Sparcl1, Tmsb4x, Fos)54,65–71, and/or resistance to chemotherapy (Crip1, Gfap, Apoe, Mt1, Mt3, Lgals1)64,69,72–74 (Fig. 9f). This evidence concerns the gene ID3 and cancer.