Alternatively, the decrease in SOX10+ cells may also be due to the upregulation of Nfia (Supplementary Data 9), a target of ASCL1 that has been shown to mutually antagonize the induction of SOX10, thus suppressing OPC/oligodendrocyte fate in favor of an NSC/astrocyte fate within glioma tumors105. Here, NFIA is linked to central nervous system cancer.