We observed differential mRNA expression of growth factors and cytokines (TGFβ, IL-6, and IGF1) both in BMSCs and, subsequently, in cancer-associated fibroblasts (CAFs), which might represent the main cell subpopulation responsible for inflammatory homeostasis in MM, among the two patient subgroups (Fig. 5d, e). The gene discussed is IGF1; the disease is Miyoshi myopathy.