We observed differential mRNA expression of growth factors and cytokines (TGFβ, IL-6, and IGF1) both in BMSCs and, subsequently, in cancer-associated fibroblasts (CAFs), which might represent the main cell subpopulation responsible for inflammatory homeostasis in MM, among the two patient subgroups (Fig. 5d, e). This evidence concerns the gene IL6 and Miyoshi myopathy.