On multivariable analysis after adjusting for age, sex, race, stage, and presence of B symptoms, patients with t-FL (hazard ratio [HR] 1.42, 95% CI, 1.24–16.2; P < 0.001) and t-LPL/WM (HR 1.65, 95% CI, 1.02–2.67; P = 0.04) had significantly higher excess hazard rates compared to patients with de novo DLBCL (Table 4). This evidence concerns the gene LPL and diffuse large B-cell lymphoma.